Symposium: Disease Modeling with iPSC: From Cells to Organoids

Symposium: Disease Modeling with iPSC: From Cells to Organoids

Tuesday, April 27, 2021 • 2:00 PM - 5:00 PM (EST)


Philip M. Iannaccone, MD, PhDChair
Philip M. Iannaccone, MD, PhD
Northwestern University 

Satdarshan Paul Singh Monga, MDCo-Chair
Satdarshan Paul Singh Monga, MD
University of Pittsburgh

Ivana Delalle, PhD, MDCo-Chair
Ivana Delalle, PhD, MD
Brown University 

Session Description: The availability of human iPSC from  various disease states presents an unprecedented opportunity to examine pathology and physiology in an intact tissue context. The decades since the early descriptions of stem cell derived “embryoid bodies”, the first example of “organoids”,  have seen major advances in directed differentiation of stem cells and their organization into small structures mimicking normal organs. Organoids can be used to interrogate altered physiology and toxicology or as test beds for therapeutic intervention. Patient derived iPSC have been used to advance our understanding of many aspects of disease states. This session will highlight recent advances in both organoids and the use of directed differentiation of human iPSC in the study of disease.


  Chair - Welcome and Introductions  
2:00 PM - 2:35 PM Cellular Regenerative Components in Liver Disease
George Michalopoulos, MD, PhD • University of Pittsburgh
 George Michalopoulos, MD, PhD
2:35 PM - 3:10 PM Emergence of Sophisticated Network and Oscillations in a Human Brain Organoid Model
Alysson Muoti, PhD • University of California, San Diego
Alysson Muoti, PhD
3:10 PM - 3:45 PM iPSC-Derived Hepatocytes to Model Ebola Virus Infection
Gustavo Mostoslavsky, MD, PhD • Boston University School of Medicine
Gustavo Mostoslavsky, MD, PhD
3:45 PM - 4:20 PM Stem CellModels of Hematopoiesis
Vasil Galat, PhD • Northwestern University
Vasil Galat, PhD
4:20 PM - 4:55 PM Modeling Genetic Epilepsies with Human iPSCs and Brain Organoids
Jenny Hsieh, PhD • University of Texas, San Antonio
Jenny Hsieh, PhD
  Questions and Answers