Philip M. Iannaccone, MD, PhD
Northwestern University Medical School
Satdarshan Paul Singh Monga, MD
University of Pittsburgh
Ivana Delalle, PhD, MD
Boston University School of Medicine
Session Description: The availability of human iPSC from various disease states presents an unprecedented opportunity to examine pathology and physiology in an intact tissue context. The decades since the early descriptions of stem cell derived “embryoid bodies”, the first example of “organoids”, have seen major advances in directed differentiation of stem cells and their organization into small structures mimicking normal organs. Organoids can be used to interrogate altered physiology and toxicology or as test beds for therapeutic intervention. Patient derived iPSC have been used to advance our understanding of many aspects of disease states. This session will highlight recent advances in both organoids and the use of directed differentiation of human iPSC in the study of disease.