Symposium: Mechanisms of Hepatic Tumorigenesis

Symposium: Mechanisms of Hepatic Tumorigenesis

Thursday, April 29, 2021 • 9:00 AM - 12:00 PM (EST)

Sponsored by the ASIP Liver Pathobiology Scientific Interest Group

 

Satdarshan Paul Singh Monga, MDChair
Satdarshan Paul Singh Monga, MD
University of Pittsburgh

Heather Francis, PhD, FAASLDCo-Chair
Heather Francis, PhD, FAASLD
Indiana University

Session Description: This symposium will provide up-to-date research (both clinical and translational) on liver cancer, specifically in hepatocellular and cholangiocarcinoma. Tumor phenotypes and signaling mechanisms will be discussed along with the role of the tumor microenvironment and cellular reprogramming. The overarching goals of this session are to provide a better understanding of the tumor microenvironment and cellular signaling events that regulate tumorigenesis in both hepatocellular and cholangiocarcinoma cancers, and to identify potential targetable components for treatment of liver cancers.

  • Chair - Welcome and Introductions
  • 9:00 AM - 9:30 AM
    From PSC to Cholangiocarcinoma: The Role of Mast Cells and Inflammation
    Heather Francis, PhD, FAASLD • Indiana University
  • 9:30 AM - 10:00 AM
    NOTCH-YAP1/TEAD-DNMT1 Axis ERegulates Hepatocyte Reprogramming into Intra-hepatic Cholangiocarcinoma
    Sungjin Ko, DVM, PhD • Univesity of Pittsburgh
  • 10:00 AM - 10:30 AM
    Beta-catenin, Tumor Microenvironment, and Immuno-oncology
    Armaia Lujambio, PhD • Mount Sinai
  • 10:30 AM - 11:00 AM
    Mechanism of Liver Metastasis Enhanced by Fatty Liver
    Ekihiro Seki, MD, PhD • Cedars Sinai Medical Center
  • 11:00 AM - 11:30 AM
    mTORC2/Akt Signaling Cascade During Hepatic Carcinogenesis
    Xin Chen, PhD • University of California, San Diego
  • 11:30 AM - 12:00 AM
    Deciphering the Anti-Oncogenic Effects of Pro-Oncogenic Molecules in the Liver
    Gen-Sheng Feng, PhD • University of California, San Diego
  • Questions and Answers