Symposium: Single Cell Transcriptome and Epigenome Analysis, Using the Power of One to Interrogate Heterogeneity

Symposium: Single Cell Transcriptome and Epigenome Analysis, Using the Power of One to Interrogate Heterogeneity

Tuesday, April 27, 2021 • 9:00 AM - 12:00 PM (EST)

 

Philip Iannaccone, MD, PhDChair
Philip Iannaccone, MD, PhD
Northwestern University Medical School

Qin Yan, PhDCo-Chair
Qin Yan, PhD
Yale School of Medicine

David C. Williams, Jr., MD, PhDCo-Chair
David C. Williams, Jr., MD, PhD
University of North Carolina, Chapel Hill

Session Description: Recent advances in transcriptomics have shown that gene expression states vary tremendously from cell to cell. This variation is essential in development where the specification of fate depends on controlled heterogeneity. In cancer, genetic and epigenetic changes results in highly heterogeneous expression states despite clonal origins. This session will present the emerging single-cell technologies in transcriptomics and epigenomics, data analysis pipeline, and the biological significance of these data.

  • Chair - Welcome and Introductions
  • 9:00 AM - 9:45 AM
    Methods for Calibration, Imputation, Visualization and Differentiation Between Samples in scRNA-seq Data Analysis
    Yuval Kluger, PhD • Yale University
  • 9:45 AM - 10:30 AM
    Single-Cell Genomics in Cancer Immunotherapy
    Ansu Satpathy, MD, PhD • Stanford University
  • 10:30 AM - 11:15 AM
    Single Cell Epigenomic Analysis of the Anatomy and Neuronal Circuitry of the Brain
    ZhuZhu Zhang, PhD • Salk Institute
  • 11:15 AM - 12:00 PM
    Integrative RNA and Chromatin Analysis of Single Cells in Human Tissues
    Kun Zhang, PhD • University of California, San Diego