Symposium: The Great Debate - Fibrosis Across Organs: Triggers, Pathways, and Cellular Plasticity

Symposium: The Great Debate - Fibrosis Across Organs: Triggers, Pathways, and Cellular Plasticity

Wednesday, April 28, 2021 • 8:30 AM - 11:30 AM (EST)

Co-Sponsored by the American Society for Matrix Biology (ASMB)

 

Titus A. Reaves, PhDChair
Titus A. Reaves, PhD
Medical University of South Carolina

Tirthadipa Pradhan-Sundd, PhDCo-Chair
Tirthadipa Pradhan-Sundd, PhD
University of Pittsburgh

Session Description: Fibrosing diseases are a broad spectrum of entities from organ-specific involvement to multi-system diseases with high morbidity and mortality and significantly unmet clinical needs. Progress in elucidating the pathogenesis of the fibroproliferative components across various diseases, including the critical roles of key cell types and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis, has highlighted many new areas of therapeutic investigation and are currently underway. This session is designed to bring together translational biomedical researchers from a wide range of disciplines to discuss complex pathophysiologic mechanisms that underlie fibrosing diseases. You won’t want to miss the hot topic debate on Power Cell – Fibroblast or Macrophage that will follow the session talks.

  • Chair - Welcome and Introductions
  • 8:30 AM - 9:00 AM
    Fibrosis in PDA Initiation and Progression Collagen Activation of DDRs as a Driver of Fibrosis and Cancer Progression
    Rolf A. Brekken, PhD • UT Southwestern Medical Center
  • 9:00 AM - 9:30 AM
    Origin of Fibrosis in the Central Nervous System
    Jae K. Lee, PhD • University of Miami Health System
  • 9:30 AM - 10:00 AM
    Toward Personalized TGFβ Inhibition for Cancer
    Huocong Huang, MD, PhD • UT Southwestern Medical Center
  • 10:00 AM - 10:30 AM
    Macrophage-Fibroblast Interactions in Fibrotic Processes
    Bryan Brown, PhD • McGowan Institute for Regenerative Medicine
  • 10:30 AM - 11:00 AM
    Heterocelluar Crosstalk in Skin Fibrosis
    Cecelia C. Yates, PhD • University of Pittsburgh
  • 11:00 AM - 11:30 AM
    State of Science Debate: Power Cell – Fibroblast or Macrophage
  • Questions and Answers