Chair
Satdarshan Paul Singh Monga, MD
University of Pittsburgh
Co-Chair
Heather Francis, PhD, FAASLD
Indiana University
Session Description: This symposium will provide up-to-date research (both clinical and translational) on liver cancer, specifically in hepatocellular and cholangiocarcinoma. Tumor phenotypes and signaling mechanisms will be discussed along with the role of the tumor microenvironment and cellular reprogramming. The overarching goals of this session are to provide a better understanding of the tumor microenvironment and cellular signaling events that regulate tumorigenesis in both hepatocellular and cholangiocarcinoma cancers, and to identify potential targetable components for treatment of liver cancers.
| Chair - Welcome and Introductions | ||
| 9:00 AM - 9:30 AM | From PSC to Cholangiocarcinoma: The Role of Mast Cells and Inflammation Heather Francis, PhD, FAASLD • Indiana University |
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| 9:30 AM - 10:00 AM | NOTCH-YAP1/TEAD-DNMT1 Axis ERegulates Hepatocyte Reprogramming into Intra-Hepatic Cholangiocarcinoma Sungjin Ko, DVM, PhD • Univesity of Pittsburgh |
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| 10:00 AM - 10:30 AM | Beta-catenin, Tumor Microenvironment, and Immuno-Oncology Armaia Lujambio, PhD • Mount Sinai |
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| 10:30 AM - 11:00 AM | Mechanism of Liver Metastasis Enhanced by Fatty Liver Ekihiro Seki, MD, PhD • Cedars Sinai Medical Center |
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| 11:00 AM - 11:30 AM | mTORC2/Akt Signaling Cascade During Hepatic Carcinogenesis Xin Chen, PhD • University of California, San Diego |
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| 11:30 AM - 12:00 PM | Deciphering the Anti-Oncogenic Effects of Pro-Oncogenic Molecules in the Liver Gen-Sheng Feng, PhD • University of California, San Diego |
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| Questions and Answers |