Chair
Titus A. Reaves, PhD
Medical University of South Carolina
Co-Chair
Mangesh Kulkarni, PhD
University of Pittsburgh
Session Description: Fibrosing diseases are a broad spectrum of entities from organ-specific involvement to multi-system diseases with high morbidity and mortality and significantly unmet clinical needs. Progress in elucidating the pathogenesis of the fibroproliferative components across various diseases, including the critical roles of key cell types and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis, has highlighted many new areas of therapeutic investigation and are currently underway. This session is designed to bring together translational biomedical researchers from a wide range of disciplines to discuss complex pathophysiologic mechanisms that underlie fibrosing diseases. You won’t want to miss the hot topic debate on Power Cell – Fibroblast or Macrophage that will follow the session talks.
| Chair - Welcome and Introductions | ||
| 8:30 AM - 9:00 AM | Fibrosis in PDA Initiation and Progression Collagen Activation of DDRs as a Driver of Fibrosis and Cancer Progression Rolf A. Brekken, PhD • UT Southwestern Medical Center |
 |
| 9:00 AM - 9:30 AM | Origin of Fibrosis in the Central Nervous System Jae K. Lee, PhD • University of Miami Health System |
 |
| 9:30 AM - 10:00 AM | Toward Personalized TGFβ Inhibition for Cancer Huocong Huang, MD, PhD • UT Southwestern Medical Center |
 |
| 10:00 AM - 10:30 AM | Macrophage-Fibroblast Interactions in Fibrotic Processes Bryan Brown, PhD • McGowan Institute for Regenerative Medicine |
 |
| 10:30 AM - 11:00 AM | Heterocelluar Crosstalk in Skin Fibrosis Cecelia C. Yates, PhD • University of Pittsburgh |
 |
| 11:00 AM - 11:30 AM | State of Science Debate: Power Cell – Fibroblast or Macrophage | |
| Questions and Answers |