Chair
Jennifer Brazil, PhD
University of Michiga
Co-Chair
Francis W. Luscinskas, PhD
Brigham & Women's Hospital
Session Description: Interactions at the immune-gastrointestinal epithelial interface are implicated in the chronic mucosal inflammation that is characteristic of inflammatory bowel disease. Immune cell intestinal epithelial interactions also play a critical role in the response to parasitic worms and during food induced anaphylactic reactions. Therefore, this symposium will highlight critical cellular and molecular interactions at the intestinal epithelial barrier under homeostasis and disease, discuss key steps that regulate the trafficking of neutrophils (key innate immune cells implicated in pathologic mucosal tissue damage) and detail how specialized epithelial cells (tuft cells) act as intestinal immune sentinels.
| Chair - Welcome and Introductions | ||
| 9:30 AM - 10:05 AM | Type-2 Immunity at the Intestinal Epithelial Barrier Simon Hogan, PhD • University of Michigan |
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| 10:05 AM - 10:40 AM | Intermittent Rolling is a Striking Defect of the Neutrophil Extravasation Cascade Caused by Myosin1e Deficiency Michael Schnoor, PhD • CINVESTAV, Mexico City, Mexico |
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| 10:40 AM - 11:15 AM | Intestinal Tuft Cells: Immune Sentinels and Effectors Jakob von Moltke, PhD • University of Washington |
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| 11:15 AM - 11:30 AM | Abstract R3672 – Gut Dysbiosis and Barrier Disruption are Associated with Diastolic Dysfunction in a Novel Mouse Model of Heart Failure with Preserved Ejection Fraction Francisco J. Carrillo-Salinas, PhD • Tufts University |
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| 11:30 AM - 11:45 AM | Abstract R2096 – Insights into the Impact of Inflammatory Acidification on the Mucosa Ian M. Cartwright, PhD • University of Colorado Anschutz Medical Campus |
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| 11:45 AM - 12:00 PM | Abstract R2078 – Structural and Chemical Alterations to the Intestinal Mucus Barrier During Giardia duodenalis Infection Elena Fekete, BSc • University of Calgary |
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| Questions and Answers |